Endocrine Abstracts

Thyrotoxicosis and primary hyperaldosteronism both cause hypokalemic periodic paralysis. A 51-year-old woman, with a history of 3 episodes of transient muscle weakness, was admitted to the emergency unit with complaint of the weakness of legs. Her medical history included hypertension for 10 years. A nodule approximately 3 cm in diameter was palpated in the left anterior neck. Decreased strength (2/5) and deep tendon reflexes in lower extremities symmetrically with normal sens...

Introduction: To assess the demographic data, etiological distribution, methods of diagnosis in patients with clinical (CS) and subclinical Cushing’s (SCC) syndrome.Methods: Forty-seven patients, 35 with CS and 12 with SCC patients were evaluated retrospectively.Results: Of the 35 patients with CS, 55% were classified as ACTH-dependent and 43% as ACTH-independent. Pituitary adenoma constituted 54% of cases, adrenal adenoma 34%...

Introduction: The prevalence of primary adrenal insufficiency (Addison disease; AD) in pregnancy is unknown. Female patients with adrenal insufficiency are usually infertile and once get pregnant are at increased risk for preterm deliveries, Cesarean section and babies with low birth weights. Recognition of AD during pregnancy may be difficult as many of the clinical complaints like weakness, lightheadness, syncope, nausea, vomiting, hyponatremia, and increased pigmentation ca...

Introduction: Manifestations of MEN2B include medullary carcinoma of thyroid (MCT), pheochromocytoma, and a number of somatic mutations like marfanoid habitus, mucosal neuromas, ganglioneuromatosis of the bowel. Dural ectasia results from enlargement of the spinal canal, was identified in 63–92% of patients with Marfan syndrome, however, it was not previously described in MEN2B. We detected dural ectasia in our patient with MEN2B.Case report: A 28 y...

Introduction: Celiac disease (CD) is gluten sensitive enteropathy with a wide spectrum of severity. Iron deficiency, growth retardation, shortness, delayed puberty can be seen. Osteomalacia and hypocalcemia are results of malabsorbtion of vitamin D and calcium which may cause secondary hyperparathyroidism. In untreated cases for a long period, tertiary hyperparathyroidism can also be seen due to autonomy of parathyroid glands with chronic stimulation. There are some cases of p...

Introduction: Steroid 11β-hydroxylase deficiency is a relatively rare form of congenital adrenal hyperplasia characterized by the overproduction of adrenal androgens and deoxycorticosterone. It usually presents with virilization of the female fetus, precocious puberty in male infants and hypertension with or without hypokalemia in both genders. Because of high levels of mineralocorticoids, patients rarely present with Addisonian crisis. We describe a male patient with 11&...

Introduction: The diagnosis of an increasing number of adrenal tumors, so-called ‘incidentalomas’, is the result of technological advances in imaging such as abdominal ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). We present a case of an accessory spleen mimicking a nonfunctional incidentaloma.Case: An 18-year-old boy was referred for evaluating of left adrenal mass that was detected by USG performed for ...

Introduction: We present a case investigated due to hypokalemia and diagnosed as rectal neuroendocrine tumor-related EAS.Case: A 67-year-old woman with weight loss and symptoms of lethargy, abdominal pain was referred due to low serum K+ levels. Elevated blood pressure and a rectal mass were detected at physical examination. Low serum K+, elevated ALT levels, lymphopenia, neutrophilia and metabolic alkalosis were present. Computed t...

Introduction: There have been no studies on the prevalence of primary aldosteronism (PA) in Turkey. In this study, the prevalence of PA among the hypertensive population was investigated.Methods/Design: The study was conducted among hypertensive patients, aged 16–88 years, who visited the out-patient clinic of Endocrinology from January 10th, 2011 to September 30th, 2011. 768 of the 774 consecutive hypertensive patients volunteered to participate. T...

Introduction: Polycystic ovary syndrome (PCOS) is a heterogenous disease with well established metabolic abnormalities among women of reproductive age. There are various diagnostic criteria to define and establish PCOS. However, there are some conflicting data regarding the the optimal diagnostic criteria for PCOS and the metabolic consequences. We evaluated the clinical, endocrine and metabolic features between main PCOS phenotypes according to different diagnostic criteria.<...